Migratory pulmonary infiltrates in a patient with rheumatoid arthritis
Identifieur interne : 002206 ( Main/Exploration ); précédent : 002205; suivant : 002207Migratory pulmonary infiltrates in a patient with rheumatoid arthritis
Auteurs : S. Mehandru [États-Unis] ; R L Smith [États-Unis] ; G S Sidhu [États-Unis] ; N. Cassai [États-Unis] ; C P Aranda [États-Unis]Source :
- Thorax [ 0040-6376 ] ; 2002-05.
English descriptors
- KwdEn :
- Teeft :
- Alveolar damage, Arterial blood, Biopsy, Biopsy specimen, Bronchial responsiveness, Bronchiolitis obliterans, Case report, Celecoxib, Chest radiograph, Clinical improvement, Diagnostic criteria, Diffuse alveolar, Diffuse alveolar damage, Early organisation, Eosinophil, Eosinophilic, Exercise tolerance, Fibrinous exudate, Hypersensitivity, Infiltrates, Inhibitor celecoxib, Interstitial infiltrates, Lung disease, Lung parenchyma, Many eosinophils, Mehandru, Organisation, Organising pneumonia, Pneumonia, Pulmonary toxicity, Radiograph, Rheumatoid, Rheumatoid arthritis, Right middle lobe, Severe shortness, Steroid, Sulfasalazine, Syndrome, Unilateral presentation.
Abstract
The case history is described of an elderly man with rheumatoid arthritis receiving treatment with sulfasalazine and the cyclooxygenase-2 inhibitor celecoxib who presented with severe shortness of breath, cough, and decreased exercise tolerance. The chest radiograph showed unilateral alveolo-interstitial infiltrates and a biopsy specimen of the lung parenchyma showed changes consistent with acute eosinophilic pneumonia. Antibiotic treatment was unsuccessful, but treatment with steroids and discontinuation of sulfasalazine and celecoxib resulted in a marked clinical improvement confirmed by arterial blood gas analysis. The condition may have developed as an adverse reaction either to sulfasalazine or to celecoxib, although hypersensitivity to the latter has not previously been reported.
Url:
DOI: 10.1136/thorax.57.5.465
Affiliations:
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The chest radiograph showed unilateral alveolo-interstitial infiltrates and a biopsy specimen of the lung parenchyma showed changes consistent with acute eosinophilic pneumonia. Antibiotic treatment was unsuccessful, but treatment with steroids and discontinuation of sulfasalazine and celecoxib resulted in a marked clinical improvement confirmed by arterial blood gas analysis. The condition may have developed as an adverse reaction either to sulfasalazine or to celecoxib, although hypersensitivity to the latter has not previously been reported.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Mehandru, S" sort="Mehandru, S" uniqKey="Mehandru S" first="S" last="Mehandru">S. Mehandru</name></region><name sortKey="Aranda, C P" sort="Aranda, C P" uniqKey="Aranda C" first="C P" last="Aranda">C P Aranda</name><name sortKey="Cassai, N" sort="Cassai, N" uniqKey="Cassai N" first="N" last="Cassai">N. Cassai</name><name sortKey="Sidhu, G S" sort="Sidhu, G S" uniqKey="Sidhu G" first="G S" last="Sidhu">G S Sidhu</name><name sortKey="Smith, R L" sort="Smith, R L" uniqKey="Smith R" first="R L" last="Smith">R L Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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